Globally, governments and medical charities spend millions of taxpayer and fundraiser dollars on biomedical research into this condition. The global cost of AD and dementia is estimated to be $605 billion, which is equivalent to 1% of the entire world’s gross domestic product. Worldwide, at least 50 million people are currently believed to be living with AD or other dementias and this number could exceed 152 million by 2050 ( ). Inheritable AD (familial AD) represents less than 5% of AD cases of which 10–15% have a family history of autosomal dominant inheritance whereas the more common, sporadic, AD with complex polygenic risk inheritance accounts for more than 90% of cases. How to use the Complex Portal is described by Meldal et al.Īlzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by loss of memory, inability to process new information, loss of language function, a disturbed perception of space, inability to do calculations, indifference, depression, delusions, and eventually death. Extensive tutorial materials on Cytoscape network building and analysis are available at, the use of ClueGO is specifically described by Bindea et al. Data required to create AD-focused molecular interaction network can be obtained by pasting the query annot: “dataset:Alzheimers” into the IntAct website ( ) with further details on how to use this resource available at. Tutorials on how to search UniProt and use the tools made available by this resource and how to access data pertaining to AD in the GO are available. An introduction to the QuickGO Gene Ontology browser can be found at. UniProtKB records in which disease is caused by mutations affecting the gene represented in that entry can be found by searching with the term “keyword:”Alzheimer disease ”.
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